Values of a novel comprehensive prognostic nutritional index (FIDA) in the prognosis of non-small cell lung cancer
| Autor: | Han Qiao, Yan Feng, Xiaolei Han, Huaping Tang |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Frontiers in Oncology, Vol 14 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2234-943X 70675341 |
| DOI: | 10.3389/fonc.2024.1393684 |
| Popis: | BackgroundThis study focuses on determining the prognostic and predictive value of the comprehensive prognostic nutrition index (FIDA) in individuals undergoing treatment for Non-Small-Cell Lung Carcinoma (NSCLC).MethodsThis retrospective analysis encompassed 474 of NSCLC patients treated from January 2010 through December 2019. Employing the Lasso-COX regression approach, eight blood parameters were identified as significant prognostic indicators. These parameters contributed to the formulation of the comprehensive prognostic nutrition index FIDA. Utilizing X-tile software, the patient cohort was categorized into either a high or low FIDA group based on an established optimal threshold. The cohort was then randomly segmented into a training set and a validation set using SPSS software. Subsequent steps involved conducting univariate and multivariate regression analyze to develop a prognostic nomogram. The effectiveness of this nomogram was evaluated by calculating the AUC.ResultsAnalysis of survival curves for both the training and validation sets revealed a poorer prognosis in the high FIDA group compared to the low FIDA group. This trend persisted across various subgroups, including gender, age, and smoking history, with a statistical significance (p |
| Databáze: | Directory of Open Access Journals |
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