B cells: roles in physiology and pathology of pregnancy

Autor: Jin-Chuan Liu, Qunxiong Zeng, Yong-Gang Duan, William S. B. Yeung, Raymond H. W. Li, Ernest H. Y. Ng, Ka-Wang Cheung, Qingqing Zhang, Philip C. N. Chiu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Immunology, Vol 15 (2024)
Druh dokumentu: article
ISSN: 1664-3224
DOI: 10.3389/fimmu.2024.1456171
Popis: B cells constitute a diverse and adaptable immune cell population with functions that can vary according to the environment and circumstances. The involvement of B cells in pregnancy, as well as the associated molecular pathways, has yet to be investigated. This review consolidates current knowledge on B cell activities and regulation during pregnancy, with a particular focus on the roles of various B cell subsets and the effects of B cell-derived factors on pregnancy outcomes. Moreover, the review examines the significance of B cell-associated autoantibodies, cytokines, and signaling pathways in relation to pregnancy complications such as pregnancy loss, preeclampsia, and preterm birth.
Databáze: Directory of Open Access Journals