Association between vitamin D receptor gene (BsmI-rs1544410 and FokI-rs2228570) polymorphisms and type 1 diabetes mellitus in Egyptian children
| Autor: | Eman A Rashed, Abeer M Mohyi, Mona M A. AbdulLatif, Dina M El-Abd, Ghada A Omar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Journal of Medicine in Scientific Research, Vol 5, Iss 2, Pp 93-97 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2537-091X 2537-0928 |
| DOI: | 10.4103/jmisr.jmisr_4_22 |
| Popis: | Introduction Type 1 diabetes mellitus (T1DM) is an autoimmune disorder triggered by both environmental and genetic risk factors. Although some studies have reported that single-nucleotide polymorphisms of vitamin D receptor (VDR) gene play a role in T1DM susceptibility, their associations are inconclusive and remain controversial in different ethnic groups. This case–control study aimed to evaluate the association between VDR (BsmI-rs1544410 and FokI-rs2228570) single-nucleotide polymorphisms and T1DM in Egyptian children. A total of 100 participants, 50 children with T1DM (cases) and 50 nondiabetic, age-matched and sex-matched patients (controls), were enrolled in the study in which BsmI-rs1544410 and FokI-rs2228570 variants were genotyped using TaqMan real-time PCR technology. Results VDR gene (BsmI-rs1544410 and FokI-rs2228570) variants are not associated with T1DM in Egyptian children. Conclusions VDR (BsmI-rs1544410 and FokI-rs2228570) variants did not differ significantly between T1DM cases and nondiabetic controls among Egyptian children. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|