Exploring the Role of Ubiquitin-Proteasome System in the Pathogenesis of Parkinson’s Disease

Autor:	Yiting Zhao, Man Lin, Fengguang Zhai, Jun Chen, Xiaofeng Jin
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Parkinson’s disease E3 ligase deubiquitination enzyme PD etiology ubiquitin-proteasome system (UPS) Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 17, Iss 6, p 782 (2024)
Druh dokumentu:	article
ISSN:	1424-8247
DOI:	10.3390/ph17060782
Popis:	Parkinson’s disease (PD) is a prevalent neurodegenerative disorder among the elderly population. The pathogenesis of PD encompasses genetic alterations, environmental factors, and age-related neurodegenerative processes. Numerous studies have demonstrated that aberrant functioning of the ubiquitin–proteasome system (UPS) plays a crucial role in the initiation and progression of PD. Notably, E3 ubiquitin ligases serve as pivotal components determining substrate specificity within UPS and are intimately associated with the regulation of various proteins implicated in PD pathology. This review comprehensively summarizes the mechanisms by which E3 ubiquitin ligases and deubiquitinating enzymes modulate PD-associated proteins and signaling pathways, while exploring the intricate relationship between UPS dysfunctions and PD etiology. Furthermore, this article discusses recent research advancements regarding inhibitors targeting PD-related E3 ubiquitin ligases.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/a000502c91a04275b1fb0b2a7b3a52af Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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