Investigation of phytochemicals, spectral properties, anticancer, antidiabetic, and antimicrobial activities of chosen Ayurvedic remedies
| Autor: | Shareef, T. H. Mohamed Ahadu, Navabshan, Irfan, Masood, M Mohamed Divan, Yuvaraj, T. Eswara, Sherif, A. |
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| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | J.Hasty Results 1 (2008) 1-9; Erratum: J.Hasty Results 2 (2008) 1-2 |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1016/S0550-3213(01)00405-9 |
| Popis: | This study examines the phytochemical characteristics of Ayurvedic products. An analysis was performed on Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J) using GC-MS and LC-MS techniques to determine their bioactive constituents, while also assessing their antimicrobial, docking, anticancer, and anti-diabetic activities. The GC-MS analysis identified 30, 45, and 8 chemical components in Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J), respectively. The LC-MS analysis produced 15, 20, and 16 peaks for Kottakkal Ayurveda Triphala (T), Kottakkal Ayurveda Hinguvachadi Churnam (H), and Kottakkal Ayurveda Jirakadyarishtam (J), with m/z values of 982, 981, 972, and 933; 987, 985, 974, and 945; and 969, 965, 951, and 941, respectively, confirming their precision. Moreover, characterization of the Ayurvedic products was carried out using FT-IR, UV-vis, and 1H-NMR spectroscopy to identify significant functional groups and chemical substances. Kottakkal Ayurveda Triphala (T) was evaluated for antibacterial activity against Gram-positive bacteria (Streptococcus pneumoniae and Staphylococcus aureus) along with Gram-negative bacteria (Escherichia coli and Klebsiella pneumoniae), yielding a P value of 0.0650 (P < 0.0001). Both Kottakkal Ayurveda Hinguvachadi Churnam (H) and Kottakkal Ayurveda Jirakadyarishtam (J) were subjected to analysis for their effectiveness against Aspergillus niger and Aspergillus fumigatus, also revealing a P value within the acceptable range of 0.0650 (P < 0.0001). The anti-diabetic properties of Kottakkal Ayurveda Triphala (T) were assessed using the {\alpha}-glucosidase inhibitory method, which exhibited a significant inhibitory effect on {\alpha}-glucosidase, resulting in an average P value of 0.001 (P < 0.0001). Comment: for associated mpeg file, see http://myhost.domain/file.mpg |
| Databáze: | arXiv |
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