A conceptual framework for modeling a latching mechanism for cell cycle regulation
| Autor: | Gandhi, Punit, Wang, Yangyang |
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| Rok vydání: | 2024 |
| Předmět: | |
| Druh dokumentu: | Working Paper |
| Popis: | Two identical van der Pol oscillators with mutual inhibition are considered as a conceptual framework for modeling a latching mechanism for cell cycle regulation. In particular, the oscillators are biased to a latched state in which there is a globally attracting steady-state equilibrium without coupling. The inhibitory coupling induces stable alternating large-amplitude oscillations that model the normal cell cycle. A homoclinic bifurcation within the model is found to be responsible for the transition from normal cell cycling to endocycles in which only one of the two oscillators undergoes large-amplitude oscillations. |
| Databáze: | arXiv |
| Externí odkaz: |
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