| Autor: |
Sun, Jiacheng, Li, Fajun, Wang, Xudong, He, Jing, Ni, Dangwu, Wang, Lang, Lin, Shaowei, Min, Qiu, Zhu, Jinfeng, Wen, Liaoyong |
| Rok vydání: |
2024 |
| Předmět: |
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| Druh dokumentu: |
Working Paper |
| Popis: |
Optical metasurface has brought a revolution in label-free molecular sensing, attracting extensive attention. Currently, such sensing approaches are being designed to respond to peak wavelengths with a higher Q factor in the visible and near-infrared regions.Nevertheless, a higher Q factor that enhances light confinement will inevitably deteriorate the wavelength sensitivity and complicate the sensing system. We propose a Q-switched sensing mechanism, which enables the real part of the refractive index to effectively perturbate the damping loss of the oscillator, resulting in a boost of peak intensity.Consequently, a higher Q factor in Q-switched sensor can further enhance the peak sensitivity while remaining compatible with broadband light sources, simultaneously meeting the requirements of high performance and a compact system.This is achieved in a unique 3D bound-state-in-continuum (BIC) metasurface which can be mass-produced by wafer-scale aluminum-nanoimprinting technology and provides a peak intensity sensitivity up to 928 %/RIU.Therefore, a miniaturized BIC biosensing system is realized, with a limit of detection to 10E-5 refractive index units and 129 aM extracellular vesicles in clinical lung cancer diagnosis, both of which are magnitudes lower than those of current state-of-the-art biosensors. It further demonstrates significant potential for home cancer self-testing equipment for post-operative follow-up. This Q-switched sensing mechanism offers a new perspective for the commercialization of advanced and practical BIC optical biosensing systems in real-setting scenarios. |
| Databáze: |
arXiv |
| Externí odkaz: |
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