| Popis: |
Parkinson's Disease afflicts millions of individuals globally. Emerging as a promising brain rehabilitation therapy for Parkinson's Disease, Closed-loop Deep Brain Stimulation (CL-DBS) aims to alleviate motor symptoms. The CL-DBS system comprises an implanted battery-powered medical device in the chest that sends stimulation signals to the brains of patients. These electrical stimulation signals are delivered to targeted brain regions via electrodes, with the magnitude of stimuli adjustable. However, current CL-DBS systems utilize energy-inefficient approaches, including reinforcement learning, fuzzy interface, and field-programmable gate array (FPGA), among others. These approaches make the traditional CL-DBS system impractical for implanted and wearable medical devices. This research proposes a novel neuromorphic approach that builds upon Leaky Integrate and Fire neuron (LIF) controllers to adjust the magnitude of DBS electric signals according to the various severities of PD patients. Our neuromorphic controllers, on-off LIF controller, and dual LIF controller, successfully reduced the power consumption of CL-DBS systems by 19% and 56%, respectively. Meanwhile, the suppression efficiency increased by 4.7% and 6.77%. Additionally, to address the data scarcity of Parkinson's Disease symptoms, we built Parkinson's Disease datasets that include the raw neural activities from the subthalamic nucleus at beta oscillations, which are typical physiological biomarkers for Parkinson's Disease. |
