| Autor: |
Kamsma, T. M., Klop, M. S., Boon, W. Q., Spitoni, C., Rueckauer, B., van Roij, R. |
| Rok vydání: |
2024 |
| Předmět: |
|
| Druh dokumentu: |
Working Paper |
| Popis: |
Fluidic iontronics offer a unique capability for emulating the chemical processes found in neurons. We extract multiple distinct chemically regulated synaptic features from a single conical microfluidic channel carrying functionalized surface groups, using finite-element calculations of continuum transport equations. Such channels have long been employed for fluidic sensing and are therefore experimentally well established. By modeling a Langmuir-type surface reaction on the channel wall we couple fast voltage-induced volumetric salt accumulation with a long-term channel surface charge modulation by means of fast charging and slow discharging. These nonlinear charging dynamics are understood through an analytic approximation rooted in first-principles. We show how short-and long-term potentiation and depression, frequency-dependent plasticity, and chemical-electrical signal coincidence detection (acting like a chemical-electrical AND logic gate), akin to the NMDA mechanism for Hebbian learning in biological synapses, can all be emulated with a single channel. |
| Databáze: |
arXiv |
| Externí odkaz: |
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