Segmentation-Free Outcome Prediction in Head and Neck Cancer: Deep Learning-based Feature Extraction from Multi-Angle Maximum Intensity Projections (MA-MIPs) of PET Images
| Autor: | Toosi, Amirhosein, Shiri, Isaac, Zaidi, Habib, Rahmim, Arman |
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| Rok vydání: | 2024 |
| Předmět: | |
| Druh dokumentu: | Working Paper |
| Popis: | We introduce an innovative, simple, effective segmentation-free approach for outcome prediction in head \& neck cancer (HNC) patients. By harnessing deep learning-based feature extraction techniques and multi-angle maximum intensity projections (MA-MIPs) applied to Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) volumes, our proposed method eliminates the need for manual segmentations of regions-of-interest (ROIs) such as primary tumors and involved lymph nodes. Instead, a state-of-the-art object detection model is trained to perform automatic cropping of the head and neck region on the PET volumes. A pre-trained deep convolutional neural network backbone is then utilized to extract deep features from MA-MIPs obtained from 72 multi-angel axial rotations of the cropped PET volumes. These deep features extracted from multiple projection views of the PET volumes are then aggregated and fused, and employed to perform recurrence-free survival analysis on a cohort of 489 HNC patients. The proposed approach outperforms the best performing method on the target dataset for the task of recurrence-free survival analysis. By circumventing the manual delineation of the malignancies on the FDG PET-CT images, our approach eliminates the dependency on subjective interpretations and highly enhances the reproducibility of the proposed survival analysis method. Comment: 15 pages, 4 tables, 4 figures. Submitted for European Journal of Nuclear Medicine and Medical Imaging |
| Databáze: | arXiv |
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