Modeling principles for a physiology-based whole-body model of human metabolism

Autor:	Blicher, Laura Hjort, Carstensen, Peter Emil, Bendsen, Jacob, Linden, Henrik, Hald, Bjørn, Kristensen, Kim, Jørgensen, John Bagterp
Rok vydání:	2024
Předmět:	Quantitative Biology - Quantitative Methods
Druh dokumentu:	Working Paper
Popis:	Physiological whole-body models are valuable tools for the development of novel drugs where understanding the system aspects is important. This paper presents a generalized model that encapsulates the structure and flow of whole-body human physiology. The model contains vascular, interstitial, and cellular subcompartments for each organ. Scaling of volumes and blood flows is described to allow for investigation across populations or specific patient groups. The model equations and the corresponding parameters are presented along with a catalog of functions that can be used to define the organ transport model and the biochemical reaction model. A simple example illustrates the procedure. Comment: 6 pages, 3 figures, 3 tables, submitted to be presented at a conference
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2404.14224 Zobrazit plný text záznamu View this record from Arxiv