Multiphase Field Model of Cells on a Substrate: From 3D to 2D

Autor:	Chiang, Michael, Hopkins, Austin, Loewe, Benjamin, Marenduzzo, Davide, Marchetti, M. Cristina
Rok vydání:	2024
Předmět:	Condensed Matter - Soft Condensed Matter Physics - Biological Physics
Druh dokumentu:	Working Paper
Popis:	Multiphase field models have emerged as an important computational tool for understanding biological tissue while resolving single-cell properties. While they have successfully reproduced many experimentally observed behaviors of living tissue, the theoretical underpinnings have not been fully explored. We show that a two-dimensional version of the model, which is commonly employed to study tissue monolayers, can be derived from a three-dimensional version in the presence of a substrate. We also show how viscous forces, which arise from friction between different cells, can be included in the model. Finally, we numerically simulate a tissue monolayer, and find that intercellular friction tends to solidify the tissue. Comment: 16 pages, 4 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2403.10715 Zobrazit plný text záznamu View this record from Arxiv