A quantitative assessment of Geant4 for predicting the yield and distribution of positron-emitting fragments in ion beam therapy
| Autor: | Chacon, Andrew, Rutherford, Harley, Hamato, Akram, Nitta, Munetaka, Nishikido, Fumihiko, Iwao, Yuma, Tashima, Hideaki, Yoshida, Eiji, Akamatsu, Go, Takyu, Sodai, Kang, Han Gyu, Franklin, Daniel R., Parodi, Katia, Yamaya, Taiga, Rosenfeld, Anatoly, Guatelli, Susanna, Safavi-Naeini, Mitra |
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| Rok vydání: | 2024 |
| Předmět: | |
| Druh dokumentu: | Working Paper |
| Popis: | Purpose: To compare the accuracy with which different hadronic inelastic physics models across ten Geant4 Monte Carlo simulation toolkit versions can predict positron-emitting fragments produced along the beam path during carbon and oxygen ion therapy. Materials and Methods: Phantoms of polyethylene, gelatin or poly(methyl methacrylate) were irradiated with monoenergetic carbon and oxygen ion beams. Post-irradiation, 4D PET images were acquired and parent $^{11}$C, $^{10}$C and $^{15}$O radionuclides contributions in each voxel were determined from the extracted time activity curves. Experiments were simulated in Geant4 Monte Carlo versions 10-11.1, with three different fragmentation models: binary ion cascade (BIC), quantum molecular dynamics (QMD) and the Liege intranuclear cascade (INCL++) - 30 combinations. Total/parent isotope positron annihilation yields were compared between simulations and experiments using normalised mean squared error and Pearson cross-correlation coefficient. Depth of maximum/distal 50\% peak position yield were also compared. Results: Performance varied considerably across versions and models, with no one best predicting all positron-emitting fragments. BIC in Geant4 10.2 provided the best overall agreement with experimental results in the largest number of test cases. QMD consistently provided the best estimates of both the depth of peak positron yield (10.4 and 10.6) and the distal 50\%-of-peak point (10.2), while BIC also performed well and INCL generally performed the worst across most Geant4 versions. Conclusions: Best spatial prediction of annihilation yield and positron-emitting fragment production during carbon and oxygen ion therapy was found to be 10.2.p03 with BIC or QMD. These version/model combinations are recommended for future heavy ion therapy research. Comment: This manuscript has been submitted to IOP's Journal of Physics in Medicine and Biology, on the 5th of February 2024 |
| Databáze: | arXiv |
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