Proton-CAT: a Novel Strategy for Enhanced Proton Therapy
| Autor: | Sun, Zhao, He, Zhencen, He, Zhuohang, Wu, Junxiang, Deng, Liyuan, Chen, Ziqi, Jiang, Junkang, Zhu, Hang, Zhang, Shuyu, Hu, Zhimin |
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| Rok vydání: | 2024 |
| Předmět: | |
| Druh dokumentu: | Working Paper |
| Popis: | We present a nitrogen-targeting-Proton-Carbon-Alpha-Therapy method, abbreviated as Proton-CAT, which partially converts protons into carbon-12 and $\alpha$ particles through nuclear reactions between protons and nitrogen-15. Monte Carlo simulations validated the effectiveness of the Proton-CAT, and the study specifically focused on the distribution of relative energy deposition. The results indicated that the presence of nitrogen-15 enhanced the maximum dose level of protons, resulting in more effective damage confined to tumor cells. Statistical analysis of secondary ions has shown that the Proton-CAT significantly increases the production efficiencies of carbon-12 and $\alpha$ particles. Furthermore, it has been revealed that elevating the nitrogen-15 concentration significantly boosts the dose of carbon and $\alpha$ particles within the tumor region. The present work would contribute to the future development of proton therapy. Comment: 5 pages, 4figures |
| Databáze: | arXiv |
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