Multiple possible patterns can emerge from virus-immune coevolution

Autor:	Kessler, David A., Levine, Herbert
Rok vydání:	2023
Předmět:	Quantitative Biology - Populations and Evolution Condensed Matter - Statistical Mechanics Nonlinear Sciences - Pattern Formation and Solitons
Druh dokumentu:	Working Paper
Popis:	The adaptive immune system engages in an arms race with evolving viruses, trying to generate new responses to viral strains that continually move away from the set of variants that have already elicited a functional immune response. In previous work, it has been argued that this dynamical process can lead to a propagating pulse of ever-changing viral population and concomitant immune response. Here, we introduce a new stochastic model of viral-host coevolution and a deterministic approximation thereof with which to study these dynamics. We show that there is indeed a possible pulse solution, but for a large host population size, the pulse becomes unstable to the generation of new infections in its wake, leading to an extended endemic infection pattern. This time-dependent endemic pattern eventually reaches a fluctuating steady-state when the infected population size reaches a large enough fraction of the total number of hosts. Comment: Revised version
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2311.00417 Zobrazit plný text záznamu View this record from Arxiv