Fast protein backbone generation with SE(3) flow matching

Autor:	Yim, Jason, Campbell, Andrew, Foong, Andrew Y. K., Gastegger, Michael, Jiménez-Luna, José, Lewis, Sarah, Satorras, Victor Garcia, Veeling, Bastiaan S., Barzilay, Regina, Jaakkola, Tommi, Noé, Frank
Rok vydání:	2023
Předmět:	Quantitative Biology - Quantitative Methods
Druh dokumentu:	Working Paper
Popis:	We present FrameFlow, a method for fast protein backbone generation using SE(3) flow matching. Specifically, we adapt FrameDiff, a state-of-the-art diffusion model, to the flow-matching generative modeling paradigm. We show how flow matching can be applied on SE(3) and propose modifications during training to effectively learn the vector field. Compared to FrameDiff, FrameFlow requires five times fewer sampling timesteps while achieving two fold better designability. The ability to generate high quality protein samples at a fraction of the cost of previous methods paves the way towards more efficient generative models in de novo protein design. Comment: Preprint
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2310.05297 Zobrazit plný text záznamu View this record from Arxiv