The motility-matrix production switch in Bacillus subtilis -- a modeling perspective

Autor:	Dannenberg, Simon, Penning, Jonas, Simm, Alexander, Klumpp, Stefan
Rok vydání:	2023
Předmět:	Physics - Biological Physics Nonlinear Sciences - Chaotic Dynamics Quantitative Biology - Cell Behavior Quantitative Biology - Molecular Networks Quantitative Biology - Quantitative Methods
Druh dokumentu:	Working Paper
Popis:	Phenotype switching can be triggered by external stimuli and by intrinsic stochasticity. Here, we focus on the motility-matrix production switch in Bacillus subtilis. We use modeling to describe the SinR-SlrR bistable switch its regulation by SinI, and to distinguish different sources of stochasticity. Our simulations indicate that intrinsic fluctuations in the synthesis of SinI are insufficient to drive spontaneous switching and suggest that switching is triggered by upstream noise from the Spo0A phosphorelay.
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2308.12780 Zobrazit plný text záznamu View this record from Arxiv