| Autor: |
Wang, Jixian, Zhang, Hongtao, Tiwari, Ram |
| Rok vydání: |
2023 |
| Předmět: |
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| Druh dokumentu: |
Working Paper |
| Popis: |
To use historical controls for indirect comparison with single-arm trials, the population difference between data sources should be adjusted to reduce confounding bias. The adjustment is more difficult for time-to-event data with a cure fraction. We propose different adjustment approaches based on pseudo observations and calibration weighting by entropy balancing. We show a simple way to obtain the pseudo observations for the cure rate and propose a simple weighted estimator based on them. Estimation of the survival function in presence of a cure fraction is also considered. Simulations are conducted to examine the proposed approaches. An application to a breast cancer study is presented. |
| Databáze: |
arXiv |
| Externí odkaz: |
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