Astrocytic gliotransmission as a pathway for stable stimulation of post-synaptic spiking: Implications for working memory

Autor:	Würzbauer, Valentin, Lenk, Kerstin, Jafarian, Matin
Rok vydání:	2023
Předmět:	Electrical Engineering and Systems Science - Systems and Control
Druh dokumentu:	Working Paper
Popis:	The brain consists not only of neurons but also of non-neuronal cells, including astrocytes. Recent discoveries in neuroscience suggest that astrocytes directly regulate neuronal activity by releasing gliotransmitters such as glutamate. In this paper, we consider a biologically plausible mathematical model of a tripartite neuron-astrocyte network. We study the stability of the nonlinear astrocyte dynamics, as well as its role in regulating the firing rate of the post-synaptic neuron. We show that astrocytes enable storing neuronal information temporarily. Motivated by recent findings on the role of astrocytes in explaining mechanisms of working memory, we numerically verify the utility of our analysis in showing the possibility of two competing theories of persistent and sparse neuronal activity of working memory. Comment: IFAC World Congress (2023)
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2304.06004 Zobrazit plný text záznamu View this record from Arxiv