Universal Transitions between Growth and Dormancy via Intermediate Complex Formation

Autor:	Yamagishi, Jumpei F., Kaneko, Kunihiko
Rok vydání:	2023
Předmět:	Quantitative Biology - Cell Behavior Physics - Biological Physics
Druh dokumentu:	Working Paper
Popis:	A simple cell model consisting of a catalytic reaction network with intermediate complex formation is numerically studied. As nutrients are depleted, the transition from the exponential growth phase to the growth-arrested dormant phase occurs along with hysteresis and a lag time for growth recovery. This transition is caused by the accumulation of intermediate complexes, leading to the jamming of reactions and the diversification of components. These properties are generic in random reaction networks, as supported by dynamical systems analyses of corresponding mean-field models. Comment: 6+6 pages, 3+6 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2304.04239 Zobrazit plný text záznamu View this record from Arxiv