Design and analysis of a microplate assay in the presence of multiple restrictions on the randomization

Autor:	Bohyn, Alexandre, Schoen, Eric D., Ng, Chee Ping, Bishard, Kristina, Haarmans, Manon, Trietsch, Sebastian J., Goos, Peter
Rok vydání:	2023
Předmět:	Statistics - Applications
Druh dokumentu:	Working Paper
DOI:	10.1007/s13253-023-00570-1
Popis:	Experiments using multi-step protocols often involve several restrictions on the randomization. For a specific application to in vitro testing on microplates, a design was required with both a split-plot and a strip-plot structure. On top of two-level treatment factors and the factors that define the randomization restrictions, a multi-level fixed blocking factor not involving further restrictions on the randomization had to be added. We develop a step-by-step approach to construct a design for the microplate experiment and analyze a response. To consolidate the approach, we study various alternative scenarios for the experiment. Comment: 31 pages, 13 tables, 4 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2303.05817 Zobrazit plný text záznamu View this record from Arxiv