| Autor: |
Chatterjee, Purba, Fancher, Sean, Katifori, Eleni |
| Rok vydání: |
2022 |
| Předmět: |
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| Druh dokumentu: |
Working Paper |
| Popis: |
Existing models of adaptation in biological flow networks consider their constituent vessels (e.g. veins and arteries) to be rigid, thus predicting a non physiological response when the drive (e.g. the heart) is dynamic. Here we show that incorporating pulsatile driving and properties such as fluid inertia and vessel compliance into a general adaptation framework fundamentally changes the expected structure at steady state of a minimal one-loop network. In particular, pulsatility is observed to give rise to resonances which can stabilize loops for a much broader class of metabolic cost functions than predicted by existing theories. Our work points to the need for a more realistic treatment of adaptation in biological flow networks, especially those driven by a pulsatile source, and provides insights into pathologies that emerge when such pulsatility is disrupted in human beings. |
| Databáze: |
arXiv |
| Externí odkaz: |
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