Characterizing TMS-EEG perturbation indexes using signal energy: initial study on Alzheimer's Disease classification

Autor:	Tautan, Alexandra-Maria, Casula, Elias, Borghi, Ilaria, Maiella, Michele, Bonni, Sonia, Minei, Marilena, Assogna, Martina, Ionescu, Bogdan, Koch, Giacomo, Santarnecchi, Emiliano
Rok vydání:	2022
Předmět:	Electrical Engineering and Systems Science - Signal Processing Computer Science - Machine Learning Quantitative Biology - Neurons and Cognition I.2.1
Druh dokumentu:	Working Paper
Popis:	Transcranial Magnetic Stimulation (TMS) combined with EEG recordings (TMS-EEG) has shown great potential in the study of the brain and in particular of Alzheimer's Disease (AD). In this study, we propose an automatic method of determining the duration of TMS induced perturbation of the EEG signal as a potential metric reflecting the brain's functional alterations. A preliminary study is conducted in patients with Alzheimer's disease (AD). Three metrics for characterizing the strength and duration of TMS evoked EEG (TEP) activity are proposed and their potential in identifying AD patients from healthy controls was investigated. A dataset of TMS-EEG recordings from 17 AD and 17 healthy controls (HC) was used in our analysis. A Random Forest classification algorithm was trained on the extracted TEP metrics and its performance is evaluated in a leave-one-subject-out cross-validation. The created model showed promising results in identifying AD patients from HC with an accuracy, sensitivity and specificity of 69.32%, 72.23% and 66.41%, respectively. Comment: 4 pages, 4 figures, Accepted at 44th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Glasgow, Scotland, United Kingdome, July 11-15, 2022
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2205.03241 Zobrazit plný text záznamu View this record from Arxiv