Effects of heterogeneity on cancer: a game theory perspective

Autor:	Laruelle, Annick, Rocha, André, Manini, Claudia, López, José I, Inarra, Elena
Rok vydání:	2022
Předmět:	Quantitative Biology - Populations and Evolution Physics - Biological Physics
Druh dokumentu:	Working Paper
Popis:	In this study, we explore interactions between cancer cells by using the hawk-dove game. We analyze the heterogeneity of tumors by considering games with populations composed of 2 or 3 types of cells. We determine what strategies are evolutionarily stable in the 2-type and 3-type population games and the corresponding expected payoffs. Our results show that the payoff of the best-off cell in the 2-type population game is higher than that of the best-off cell in the 3-type population game. Translating these mathematical findings to the field of oncology suggests that a branching-type tumor pursues a less aggressive course than a punctuated-type one. Some histological and genomic data of clear cell renal cell carcinomas are consistent with these results. Comment: 16 pages, 3 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2202.02211 Zobrazit plný text záznamu View this record from Arxiv