A Glioblastoma PDE-ODE model including chemotaxis and vasculature

Autor:	Fernández-Romero, A., Guillén-González, F., Suárez, A.
Rok vydání:	2021
Předmět:	Mathematics - Analysis of PDEs Mathematics - Numerical Analysis 35A01 35B40 35M10 35Q92 47J35 92B05
Druh dokumentu:	Working Paper
DOI:	10.1051/m2an/2022012
Popis:	In this work we analyse a PDE-ODE problem modelling the evolution of a Glioblastoma, which includes chemotaxis term directed to vasculature. First, we obtain some a priori estimates for the (possible) solutions of the model. In particular, under some conditions on the parameters, we obtain that the system does not develop blow-up at finite time. In addition, we design a fully discrete finite element scheme for the model which preserves some pointwise estimates of the continuous problem. Later, we make an adimensional study in order to reduce the number of parameters. Finally, we detect the main parameters determining different width of the ring formed by proliferative and necrotic cells and different regular/irregular behaviour of the tumor surface. Comment: 25 pages, 20 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2109.14322 Zobrazit plný text záznamu Plný text ve formátu PDF