Multiscale Model of Clogging in Microfluidic Devices with Grid-Like Geometries

Autor:	Kelly, Gess, Fai, Thomas G.
Rok vydání:	2021
Předmět:	Condensed Matter - Soft Condensed Matter Physics - Fluid Dynamics 74F10 92C37 76S05
Zdroj:	Proc. R. Soc. A., 478(2261), 20220119, 2022
Druh dokumentu:	Working Paper
DOI:	10.1098/rspa.2022.0119
Popis:	We propose a coarse-grained theoretical model to capture the aging of microfluidic devices under different conditions including constant applied flow rate and constant applied pressure gradient. Microfluidic devices that sort cells by their deformability hold significant promise for medical applications. However, clogging in these microfluidic systems causes their properties to change over time and potentially limits their reliability. We compare the results of the coarse-grained model to those of stochastic simulations and to existing theoretical studies. Lastly, we apply the model to experimental data on the clogging of sickle red blood cells and discuss its wider applicability. Comment: 27 pages, 8 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2108.01570 Zobrazit plný text záznamu View this record from Arxiv