Selection, recombination, and the ancestral initiation graph

Autor: Alberti, Frederic, Herrmann, Carolin, Baake, Ellen
Rok vydání: 2021
Předmět:
Zdroj: Theor. Popul. Biol. 142 (2021) 46-56
Druh dokumentu: Working Paper
Popis: Recently, the selection-recombination equation with a single selected site and an arbitrary number of neutral sites was solved by means of the ancestral selection-recombination graph. Here, we introduce a more accessible approach, namely the ancestral initiation graph. The construction is based on a discretisation of the selection-recombination equation. We apply our method to systematically explain a long-standing observation concerning the dynamics of linkage disequilibrium between two neutral loci hitchhiking along with a selected one. In particular, this clarifies the nontrivial dependence on the position of the selected site.
Databáze: arXiv