Free-Breathing Liver Fat, $R_2^*$ and $B_0$ Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-based Reconstruction
| Autor: | Tan, Zhengguo, Unterberg-Buchwald, Christina, Blumenthal, Moritz, Scholand, Nick, Schaten, Philip, Holme, Christian, Wang, Xiaoqing, Raddatz, Dirk, Uecker, Martin |
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| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | IEEE Trans Med Imaging 2023;42:1374-1387 |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1109/TMI.2022.3228075 |
| Popis: | This work introduced a stack-of-radial multi-echo asymmetric-echo MRI sequence for free-breathing liver volumetric acquisition. Regularized model-based reconstruction was implemented in Berkeley Advanced Reconstruction Toolbox (BART) to jointly estimate all physical parameter maps (water, fat, R2*, and B0 field inhomogeneity maps) and coil sensitivity maps from self-gated k-space data. Specifically, locally low rank and temporal total variation regularization were employed directly on physical parameter maps. The proposed free-breathing radial technique was tested on a water/fat & iron phantom, a young volunteer, and obesity/diabetes/hepatic steatosis patients. Quantitative fat fraction and R2* accuracy were confirmed by comparing our technique with the reference breath-hold Cartesian scan. The multi-echo radial sampling sequence achieves fast k-space coverage and is robust to motion. Moreover, the proposed motion-resolved model-based reconstruction allows for free-breathing liver fat and R2* quantification in multiple motion states. Overall, our proposed technique offers a convenient tool for non-invasive liver assessment with no breath holding requirement. Comment: 31 pages, 13 figures |
| Databáze: | arXiv |
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