| Autor: |
Liu, Xiong, Finelli, Luca A., Hersch, Greg L., Khalil, Iya |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
2020 IEEE International Conference on Big Data (IEEE BigData 2020) |
| Druh dokumentu: |
Working Paper |
| Popis: |
COVID-19 clinical trial design is a critical task in developing therapeutics for the prevention and treatment of COVID-19. In this study, we apply a deep learning approach to extract eligibility criteria variables from COVID-19 trials to enable quantitative analysis of trial design and optimization. Specifically, we train attention-based bidirectional Long Short-Term Memory (Att-BiLSTM) models and use the optimal model to extract entities (i.e., variables) from the eligibility criteria of COVID-19 trials. We compare the performance of Att-BiLSTM with traditional ontology-based method. The result on a benchmark dataset shows that Att-BiLSTM outperforms the ontology model. Att-BiLSTM achieves a precision of 0.942, recall of 0.810, and F1 of 0.871, while the ontology model only achieves a precision of 0.715, recall of 0.659, and F1 of 0.686. Our analyses demonstrate that Att-BiLSTM is an effective approach for characterizing patient populations in COVID-19 clinical trials. |
| Databáze: |
arXiv |
| Externí odkaz: |
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