| Autor: |
Gibby, W. A. T., Barabash, M. L., Guardiani, C., Luchinsky, D. G., McClintock, P. V. E. |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Phys. Rev. Lett. 126, 218102 (2021) |
| Druh dokumentu: |
Working Paper |
| DOI: |
10.1103/PhysRevLett.126.218102 |
| Popis: |
We introduce a statistical and linear response theory of selective conduction in biological ion channels with multiple binding sites and possible point mutations. We derive an effective grand-canonical ensemble and generalised Einstein relations for the selectivity filter, assuming strongly coordinated ionic motion, and allowing for ionic Coulomb blockade. The theory agrees well with data from the KcsA K$^+$ channel and a mutant. We show that the Eisenman relations for thermodynamic selectivity follow from the condition for fast conduction and find that maximum conduction requires the binding sites to be nearly identical. |
| Databáze: |
arXiv |
| Externí odkaz: |
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