Swirling Instability of the Microtubule Cytoskeleton

Autor:	Stein, David B., De Canio, Gabriele, Lauga, Eric, Shelley, Michael J., Goldstein, Raymond E.
Rok vydání:	2020
Předmět:	Condensed Matter - Soft Condensed Matter Nonlinear Sciences - Pattern Formation and Solitons Physics - Biological Physics Quantitative Biology - Subcellular Processes
Zdroj:	Phys. Rev. Lett. 126, 028103 (2021)
Druh dokumentu:	Working Paper
DOI:	10.1103/PhysRevLett.126.028103
Popis:	In the cellular phenomena of cytoplasmic streaming, molecular motors carrying cargo along a network of microtubules entrain the surrounding fluid. The piconewton forces produced by individual motors are sufficient to deform long microtubules, as are the collective fluid flows generated by many moving motors. Studies of streaming during oocyte development in the fruit fly $D.~melanogaster$ have shown a transition from a spatially-disordered cytoskeleton, supporting flows with only short-ranged correlations, to an ordered state with a cell-spanning vortical flow. To test the hypothesis that this transition is driven by fluid-structure interactions we study a discrete-filament model and a coarse-grained continuum theory for motors moving on a deformable cytoskeleton, both of which are shown to exhibit a $swirling~instability$ to spontaneous large-scale rotational motion, as observed. Comment: 6 pages, 5 figures and Supplementay Material (5 pages, 5 figures); SM video at website of REG
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2008.12018 Zobrazit plný text záznamu View this record from Arxiv