Dynamic nuclear structure emerges from chromatin crosslinks and motors

Autor:	Liu, Kuang, Patteson, Alison E., Banigan, Edward J., Schwarz, J. M.
Rok vydání:	2020
Předmět:	Quantitative Biology - Subcellular Processes
Zdroj:	Phys. Rev. Lett. 126, 158101 (2021)
Druh dokumentu:	Working Paper
DOI:	10.1103/PhysRevLett.126.158101
Popis:	The cell nucleus houses the chromosomes, which are linked to a soft shell of lamin filaments. Experiments indicate that correlated chromosome dynamics and nuclear shape fluctuations arise from motor activity. To identify the physical mechanisms, we develop a model of an active, crosslinked Rouse chain bound to a polymeric shell. System-sized correlated motions occur but require both motor activity {\it and} crosslinks. Contractile motors, in particular, enhance chromosome dynamics by driving anomalous density fluctuations. Nuclear shape fluctuations depend on motor strength, crosslinking, and chromosome-lamina binding. Therefore, complex chromatin dynamics and nuclear shape emerge from a minimal, active chromosome-lamina system. Comment: 18 pages, 21 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2008.07417 Zobrazit plný text záznamu View this record from Arxiv