BioDynaMo: a general platform for scalable agent-based simulation

Autor:	Breitwieser, Lukas, Hesam, Ahmad, de Montigny, Jean, Vavourakis, Vasileios, Iosif, Alexandros, Jennings, Jack, Kaiser, Marcus, Manca, Marco, Di Meglio, Alberto, Al-Ars, Zaid, Rademakers, Fons, Mutlu, Onur, Bauer, Roman
Rok vydání:	2020
Předmět:	Computer Science - Computational Engineering Finance and Science Computer Science - Distributed Parallel and Cluster Computing Computer Science - Multiagent Systems
Druh dokumentu:	Working Paper
DOI:	10.1093/bioinformatics/btab649
Popis:	Motivation: Agent-based modeling is an indispensable tool for studying complex biological systems. However, existing simulators do not always take full advantage of modern hardware and often have a field-specific software design. Results: We present a novel simulation platform called BioDynaMo that alleviates both of these problems. BioDynaMo features a general-purpose and high-performance simulation engine. We demonstrate that BioDynaMo can be used to simulate use cases in: neuroscience, oncology, and epidemiology. For each use case we validate our findings with experimental data or an analytical solution. Our performance results show that BioDynaMo performs up to three orders of magnitude faster than the state-of-the-art baseline. This improvement makes it feasible to simulate each use case with one billion agents on a single server, showcasing the potential BioDynaMo has for computational biology research. Availability: BioDynaMo is an open-source project under the Apache 2.0 license and is available at www.biodynamo.org. Instructions to reproduce the results are available in supplementary information. Contact: lukas.breitwieser@inf.ethz.ch, a.s.hesam@tudelft.nl, omutlu@ethz.ch, r.bauer@surrey.ac.uk Supplementary information: Available at https://doi.org/10.5281/zenodo.4501515 Comment: 8 pages, 6 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2006.06775 Zobrazit plný text záznamu View this record from Arxiv