Modeling the molecular impact of SARS-CoV-2 infection on the renin-angiotensin system
| Autor: | Pucci, Fabrizio, Bogaerts, Philippe, Rooman, Marianne |
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| Rok vydání: | 2020 |
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| Druh dokumentu: | Working Paper |
| Popis: | SARS-CoV-2 coronavirus infection is mediated by the binding of its spike protein to the angiotensin-converting enzyme 2 (ACE2), which plays a pivotal role in the renin-angiotensin system (RAS). The study of RAS dysregulation due to SARS-CoV-2 infection is fundamentally important for a better understanding of the pathogenic mechanisms and risk factors associated with COVID-19 coronavirus disease, and to design effective therapeutic strategies. In this context, we developed a mathematical model of RAS based on data regarding protein and peptide concentrations; the model was tested on clinical data from healthy normotensive and hypertensive individuals. We then used our model to analyze the impact of SARS-CoV-2 infection on RAS, which we modeled through a down-regulation of ACE2 as a function of viral load. We also used it to predict the effect of RAS-targeting drugs, such as RAS-blockers, human recombinant ACE2, and angiotensin 1-7 peptide, on COVID-19 patients; the model predicted an improvement of the clinical outcome for some drugs and a worsening for others. Comment: 22 pages, 5 figures. Revision 1 [section rearranged, typos fixed] |
| Databáze: | arXiv |
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