What do we know about DNA mechanics so far?

Autor:	Aggarwal, Abhishek, Naskar, Supriyo, Sahoo, Anil Kumar, Mogurampelly, Santosh, Garai, Ashok, Maiti, Prabal K.
Rok vydání:	2020
Předmět:	Physics - Biological Physics Condensed Matter - Soft Condensed Matter Condensed Matter - Statistical Mechanics Physics - Chemical Physics
Zdroj:	Current Opinion in Structural Biology 64 (2020): 42-50
Druh dokumentu:	Working Paper
DOI:	10.1016/j.sbi.2020.05.010
Popis:	The DNA molecule, apart from carrying the genetic information, plays a crucial role in a variety of biological processes and find applications in drug design, nanotechnology and nanoelectronics. The molecule undergoes significant structural transitions under the influence of forces due to physiological and non-physiological environments. Here, we summarize the insights gained from simulations and single-molecule experiments on the structural transitions and mechanics of DNA under force, as well as its elastic properties, in various environmental conditions, and discuss appealing future directions. Comment: Review Article, Accepted for publication in Current Opinion in Structural Biology
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/2006.00822 Zobrazit plný text záznamu View this record from Arxiv