Differentiation of neural-type cells on multi-scale ordered collagen-silica bionanocomposites

Autor: Debons, Nicolas, Dems, Dounia, Hélary, Christophe, Grill, Sylvain Le, Picaut, Lise, Renaud, Flore, Delsuc, Nicolas, Schanne-Klein, Marie-Claire, Coradin, Thibaud, Aimé, Carole
Rok vydání: 2020
Předmět:
Zdroj: Biomaterials Science, Royal Society of Chemistry (RSC), 2020
Druh dokumentu: Working Paper
Popis: Cells respond to biophysical and biochemical signals. We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. This combines scaffolding and signaling and shows that local tuning of collagen organization enhances cell differentiation.
Databáze: arXiv