Growth and Elasticity of Mechanically-Created Neurites

Autor:	Anthonisen, Madeleine, Grutter, Peter
Rok vydání:	2019
Předmět:	Physics - Biological Physics
Druh dokumentu:	Working Paper
Popis:	Working in the framework of morphoelasticity, we develop a model of neurite growth in response to elastic deformation. We decompose the applied stretch into an elastic component and a growth component, and adopt an observationally-motivated model for the growth law. We then compute the best-fit model parameters by fitting to force-extension curves from measurements of constant-speed uniaxial deformations of mechanically-induced neurites of rat hippocampal neurons. We find a time constant for the growth law of 0.009~s$^{-1}$, similar to the diffusion rate of actin in a cell. Our results characterize the kinematics of neurite growth and establish new limits on the growth rate of neurites. Comment: 8 pages, 7 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1912.05735 Zobrazit plný text záznamu View this record from Arxiv