Topological constraints in eukaryotic genomes and how they can be exploited to improve spatial models of chromosomes

Autor:	Rosa, Angelo, Di Stefano, Marco, Micheletti, Cristian
Rok vydání:	2019
Předmět:	Quantitative Biology - Quantitative Methods Condensed Matter - Soft Condensed Matter Quantitative Biology - Biomolecules
Druh dokumentu:	Working Paper
Popis:	Several orders of magnitude typically separate the contour length of eukaryotic chromosomes and the size of the nucleus where they are confined. The ensuing topological constraints can slow down the relaxation dynamics of genomic filaments to the point that mammalian chromosomes are never in equilibrium over a cell's lifetime. In this opinion article, we revisit these out-of-equilibrium effects and discuss how their inclusion in physical models can enhance the spatial reconstructions of interphase eukaryotic genomes from phenomenological constraints collected during interphase. Comment: 5 pages, 1 figure, opinion article, submitted for publication
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1910.08998 Zobrazit plný text záznamu View this record from Arxiv