Collective cell migration of epithelial cells driven by chiral torque generation

Autor:	Yamamoto, Takaki, Hiraiwa, Tetsuya, Shibata, Tatsuo
Rok vydání:	2019
Předmět:	Condensed Matter - Soft Condensed Matter Physics - Biological Physics
Zdroj:	Phys. Rev. Research 2, 043326 (2020)
Druh dokumentu:	Working Paper
DOI:	10.1103/PhysRevResearch.2.043326
Popis:	Various multicellular tissues show chiral morphology. Experimental studies have shown this can originate from cell chirality. However, no theory has been proposed to connect the cellular chiral torque and multicellular chiral morphogenesis. We propose a model of confluent tissue dynamics with cellular chiral torque. We found that cells migrate unidirectionally under a gradient of cellular chiral torque. While the migration speed varies depending on the tissue's mechanical parameters, it is scaled solely by a structural order parameter for liquid-to-solid transition in confluent tissues. Comment: 9 pages, 9 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1909.02771 Zobrazit plný text záznamu View this record from Arxiv