Anionic nanoparticle-lipid membrane interactions: the protonation of anionic ligands at the membrane surface reduces membrane disruption

Autor: Salassi, Sebastian, Canepa, Ester, Ferrando, Riccardo, Rossi, Giulia
Rok vydání: 2019
Předmět:
Zdroj: RSC Adv., 2019, 9, 13992
Druh dokumentu: Working Paper
DOI: 10.1039/c9ra02462j
Popis: Monolayer-protected gold nanoparticles (Au NPs) are promising biomedical tools with applications to diagnosis and therapy, thanks to their biocompatibility and versatility. Here we show how the NP surface functionalization can drive the mechanism of interaction with lipid membranes. In particular, we show that the spontaneous protonation of anionic carboxylic groups on the NP surface can make the NP-membrane interaction faster and less disruptive.
Databáze: arXiv