Convolutional nets for reconstructing neural circuits from brain images acquired by serial section electron microscopy

Autor: Lee, Kisuk, Turner, Nicholas, Macrina, Thomas, Wu, Jingpeng, Lu, Ran, Seung, H. Sebastian
Rok vydání: 2019
Předmět:
Druh dokumentu: Working Paper
Popis: Neural circuits can be reconstructed from brain images acquired by serial section electron microscopy. Image analysis has been performed by manual labor for half a century, and efforts at automation date back almost as far. Convolutional nets were first applied to neuronal boundary detection a dozen years ago, and have now achieved impressive accuracy on clean images. Robust handling of image defects is a major outstanding challenge. Convolutional nets are also being employed for other tasks in neural circuit reconstruction: finding synapses and identifying synaptic partners, extending or pruning neuronal reconstructions, and aligning serial section images to create a 3D image stack. Computational systems are being engineered to handle petavoxel images of cubic millimeter brain volumes.
Databáze: arXiv