Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating
| Autor: | Noskov, R. E., Zanishevskaya, A. A., Shuvalov, A. A., German, S. V., Inozemtseva, O. A., Kochergin, T. P., Lazareva, E. N., Tuchin, V. V., Ginzburg, P., Skibina, J. S., Gorin, D. A. |
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| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Optics Express, Vol. 27 No. 6 (2019) |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1364/OE.27.009868 |
| Popis: | Optical fibers are widely used in bioimaging systems as flexible endoscopes capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique which allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), paving the way for combing MRI and optical bioimaging. Our approach is based on Layer-by-Layer assembly of oppositely charged polyelectrolytes and magnetite nanoparticles on the inner core surface of HC-MFs. Incorporation of magnetite nanoparticles into polyelectrolyte layers renders HC-MFs visible for MRI and induces the red-shift in their transmission spectra. Specifically, the transmission shifts up to 60 nm have been revealed for the several-layers composite coating along with the high-quality contrast of HC-MFs in MRI scans. Our results shed light on marrying fiber-based endoscopy with MRI that opens novel possibilities for minimally invasive clinical diagnostics and surgical procedures in vivo. Comment: 11 pages, 6 figures |
| Databáze: | arXiv |
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