Murburn scheme for thermogenesis mediated by uncoupling protein

Autor:	Manoj, Kelath Murali, Gideon, Daniel Andrew, Jacob, Vivian David
Rok vydání:	2018
Předmět:	Quantitative Biology - Subcellular Processes
Druh dokumentu:	Working Paper
Popis:	Thermogenesis by uncoupling protein (UCP) has traditionally been explained as the dissipation of proton gradient across the inner mitochondrial membrane into heat. Herein, we propose that UCPs, aided by the large pore and positively charged amino acids of suspended loops, enable protonation and transport of DROS. Thus, UCP facilitates DROS-reactions amongst themselves, forming water and liberating heat around the inner mitochondrial membrane. Thereby, the simple murburn scheme for biothermogenesis integrates structural information of UCP with its attributed physiological function. Comment: 13 pages, 3 figures, 1 table and 4577 words in total. An original research cum hypothesis paper
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1812.06089 Zobrazit plný text záznamu View this record from Arxiv