| Autor: |
Slator, Paddy J., Hutter, Jana, Palombo, Marco, Jackson, Laurence H., Ho, Alison, Panagiotaki, Eleftheria, Chappell, Lucy C., Rutherford, Mary, Hajnal, Joseph V., Alexander, Daniel C. |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Magn Reson Med. 2019;1-12 |
| Druh dokumentu: |
Working Paper |
| DOI: |
10.1002/mrm.27733 |
| Popis: |
Purpose: A combined diffusion-relaxometry MR acquisition and analysis pipeline for in-vivo human placenta, which allows for exploration of coupling between T2* and apparent diffusion coefficient (ADC) measurements in a sub 10 minute scan time. Methods: We present a novel acquisition combining a diffusion prepared spin-echo with subsequent gradient echoes. The placentas of 17 pregnant women were scanned in-vivo, including both healthy controls and participants with various pregnancy complications. We estimate the joint T2*-ADC spectra using an inverse Laplace transform. Results: T2*-ADC spectra demonstrate clear quantitative separation between normal and dysfunctional placentas. Conclusions: Combined T2*-diffusivity MRI is promising for assessing fetal and maternal health during pregnancy. The T2*-ADC spectrum potentially provides additional information on tissue microstructure, compared to measuring these two contrasts separately. The presented method is immediately applicable to the study of other organs. |
| Databáze: |
arXiv |
| Externí odkaz: |
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