Asymmetry between Activators and Deactivators in Functional Protein Networks

Autor:	Tareen, Ammar, Wingreen, Ned S., Mukhopadhyay, Ranjan
Rok vydání:	2018
Předmět:	Quantitative Biology - Molecular Networks Physics - Biological Physics
Druh dokumentu:	Working Paper
Popis:	Are "turn-on" and "turn-off" functions in protein-protein interaction networks exact opposites of each other? To answer this question, we implement a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. We study the roles of activators and deactivators, two core components of oscillatory protein interaction networks, and find a striking asymmetry in the roles of activating and deactivating proteins, where activating proteins tend to be synergistic and deactivating proteins tend to be competitive. Comment: 7 Pages, 5 Figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1807.09431 Zobrazit plný text záznamu View this record from Arxiv