Molecular Regulation of Histamine Synthesis

Autor:	Huang, Hua, Li, Yapeng, Liang, Jinyi, Finkelman, Fred D.
Rok vydání:	2018
Předmět:	Quantitative Biology - Molecular Networks Quantitative Biology - Genomics
Druh dokumentu:	Working Paper
Popis:	Histamine is a critical mediator of IgE/ cell-mediated anaphylaxis, a neurotransmitter and a regulator of gastric acid secretion. Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Despite the importance of histamine, transcriptional regulation of HDC gene expression in mammals is still poorly understood. In this Review, we focus on discussing advances in the understanding of molecular regulation of mammalian histamine synthesis. Comment: 1.added references for introduction section; 2.added references and typos added for histamine-producing cells in mammals and stimuli that trigger histamine release; 3.typos added for section of histidine decarboxylase and histamine synthesis in mammals; 4.added references and typos added for section of hdc gene expression and histamine synthesis in basophils and mast cells. 5. added 2 figures
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1802.02540 Zobrazit plný text záznamu View this record from Arxiv