The heterodimer auto-repression loop: a robust and flexible pulse-generating genetic module

Autor:	Lannoo, B., Carlon, E., Lefranc, M.
Rok vydání:	2017
Předmět:	Quantitative Biology - Molecular Networks Physics - Biological Physics Quantitative Biology - Quantitative Methods
Zdroj:	Phys. Rev. Lett. 117, 018102 (2016)
Druh dokumentu:	Working Paper
DOI:	10.1103/PhysRevLett.117.018102
Popis:	We investigate the dynamics of the heterodimer autorepression loop (HAL), a small genetic module in which a protein A acts as an auto-repressor and binds to a second protein B to form a AB dimer. For suitable values of the rate constants the HAL produces pulses of A alternating with pulses of B. By means of analytical and numerical calculations, we show that the duration of A-pulses is extremely robust against variation of the rate constants while the duration of the B-pulses can be flexibly adjusted. The HAL is thus a minimal genetic module generating robust pulses with tunable duration an interesting property for cellular signalling. Comment: 5 pages, 5 figures and SI (6 pages)
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1705.10697 Zobrazit plný text záznamu View this record from Arxiv