Origin of spatial organization of DNA-polymer in bacterial chromosomes

Autor:	Agarwal, Tejal, Manjunath, G. P., Habib, Farhat, Chatterji, Apratim
Rok vydání:	2017
Předmět:	Condensed Matter - Soft Condensed Matter Condensed Matter - Statistical Mechanics Physics - Biological Physics
Druh dokumentu:	Working Paper
DOI:	10.1209/0295-5075/121/18004
Popis:	In-vivo DNA organization at large length scales ($\sim 100nm$) is highly debated and polymer models have proved useful to understand the principle of DNA-organization. Here, we show that $<2$% cross-links at specific points in a ring polymer can lead to a distinct spatial organization of the polymer. The specific pairs of cross-linked monomers were extracted from contact maps of bacterial DNA. We are able to predict the structure of 2 DNAs using Monte Carlo simulations of the bead-spring polymer with cross-links at these special positions. Simulations with cross-links at random positions along the chain show that the organization of the polymer is different in nature from the previous case. Comment: arXiv admin note: text overlap with arXiv:1701.05068
Databáze:	arXiv
Externí odkaz:	http://arxiv.org/abs/1701.05770 Zobrazit plný text záznamu View this record from Arxiv