A biological model of scabies infection dynamics and treatment explains why mass drug administration does not lead to elimination
| Autor: | Lydeamore, M., Campbell, P. T., Regan, D. G., Tong, S. Y. C., Andrews, R., Steer, A. C., Romani, L., Kaldor, J. M., McVernon, J., McCaw, J. M. |
|---|---|
| Rok vydání: | 2016 |
| Předmět: | |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1016/j.mbs.2018.08.007 |
| Popis: | Despite a low global prevalence, infections with Sarcoptes scabiei, or scabies, are still common in remote communities such as in northern Australia and the Solomon Islands. Mass drug administration (MDA) has been utilised in these communities, and although prevalence drops substantially initially, these reductions have not been sustained. We develop a compartmental model of scabies infection dynamics and incorporate both ovicidal and non-ovicidal treatment regimes. By including the dynamics of mass drug administration, we are able to reproduce the phenomena of an initial reduction in prevalence, followed by the recrudescence of infection levels in the population. We show that even under a `perfect' two-round MDA, eradication of scabies under a non-ovicidal treatment scheme is almost impossible. We then go on to consider how the probability of elimination varies with the number of treatment rounds delivered in an MDA. We find that even with infeasibly large numbers of treatment rounds, elimination remains challenging. Comment: 22 pages, 10 figures |
| Databáze: | arXiv |
| Externí odkaz: |
|