Modulation of synaptic plasticity by glutamatergic gliotransmission: A modeling study
| Autor: | De Pittà, Maurizio, Brunel, Nicolas |
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| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Neural Plasticity, volume 2016 (2016), Article ID 7607924 |
| Druh dokumentu: | Working Paper |
| DOI: | 10.1155/2016/7607924 |
| Popis: | Glutamatergic gliotransmission, that is the release of glutamate from perisynaptic astrocyte processes in an activity-dependent manner, has emerged as a potentially crucial signaling pathway for regulation of synaptic plasticity, yet its modes of expression and function in vivo remain unclear. Here, we focus on two experimentally well-identified gliotransmitter patwhays: (i)~modulations of synaptic release and (ii)~postynaptic slow inward currents mediated by glutamate released from astrocytes, and investigate their possible functional relevance on synaptic plasticity in a biophysical model of an astrocyte-regulated synapse. Our model predicts that both pathways could profoundly affect both short- and long-term plasticity. In particular, activity-dependent glutamate release from astrocytes, could dramatically change spike-timing--dependent plasticity, turning potentiation into depression (and vice versa) for the same protocol. Comment: 55 pages, 7 figures, 1 table |
| Databáze: | arXiv |
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